Regulation of Notch1 Signaling in THP-1 Cells Enhances M2 Macrophage
نویسندگان
چکیده
1 Regulation of Notch1 Signaling in THP-1 Cells Enhances M2 Macrophage 2 Differentiation 3 4 Reetu D. Singla, Jing Wang, and Dinender K. Singla 5 Biomolecular Science Center, Burnett School of Biomedical Sciences, College of 6 Medicine, University of Central Florida, Orlando, FL, 32816 USA 7 8 9 10 11 12 13 14 Running Title: Notch-1 in Macrophage Differentiation 15 16 17 Address for correspondence: 18 Dinender K. Singla, Ph.D. FAHA 19 Biomolecular Science Center 20 College of Medicine 21 University of Central Florida 22 4000 Central Florida Blvd, Room 224 23 Orlando, FL, 32816, USA 24 25 E-mail: [email protected] 26 Phone: 407-823-0953 27 28 29 Articles in PresS. Am J Physiol Heart Circ Physiol (September 26, 2014). doi:10.1152/ajpheart.00896.2013
منابع مشابه
Regulation of Notch 1 signaling in THP-1 cells enhances M2 macrophage differentiation.
Macrophage polarization is emerging as an important area of research for the development of novel therapeutics to treat inflammatory diseases. Within the current study, the role of Notch1R in macrophage differentiation was investigated as well as downstream effects in THP-1 monocytes cultured in "inflammation mimicry" media. Interference of Notch signaling was achieved using either the pharmace...
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